Cabergoline is a dopamine agonist primarily used for the treatment of disorders associated with high levels of the hormone prolactin, such as prolactinomas and other conditions that cause hyperprolactinemia. The pharmacological action of Cabergoline involves its selective stimulation of dopamine D2 receptors in the anterior pituitary gland, leading to the inhibition of prolactin secretion.
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Mechanism of Action
Cabergoline’s mechanism of action can be summarized as follows:
- Dopamine Receptor Agonism: Cabergoline binds to D2 dopamine receptors, mimicking the action of dopamine. This interaction decreases the secretion of prolactin from the pituitary gland.
- Reduction of Tumor Size: In patients with prolactinomas, Cabergoline often results in a reduction in tumor size, alleviating pressure symptoms and restoring normal prolactin levels.
- Improvement of Symptoms: By lowering prolactin levels, Cabergoline helps in the resolution of symptoms associated with hyperprolactinemia, which may include infertility, galactorrhea (milky nipple discharge), and menstrual irregularities.
Clinical Indications
Cabergoline is indicated for:
- Management of hyperprolactinemic disorders
- Treatment of prolactin-secreting adenomas
- Adjunct therapy in certain neurological disorders
Conclusion
Cabergoline Tablets USP manufactured by Ingenus Pharmaceuticals represent a vital option in the management of hyperprolactinemic conditions, leveraging its pharmacological action to manage and treat associated disorders effectively.